Therapeutic potential of Liver Receptor Homolog-1 modulators

@article{Lazarus2012TherapeuticPO,
  title={Therapeutic potential of Liver Receptor Homolog-1 modulators},
  author={Kyren A. Lazarus and Dhilushi Dodampege Wijayakumara and Ashwini L Chand and Evan R. Simpson and Colin Clyne},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2012},
  volume={130},
  pages={138-146}
}
Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early development, cholesterol homeostasis, steroidogenesis and certain diseases, including cancer. It is expressed in embryonic stem cells, adult liver, intestine, pancreas and ovary. It binds to DNA as a monomer and is regulated by various ligand-dependent and -independent mechanisms. Recent work identified synthetic ligands for LRH-1; such compounds may yield useful… CONTINUE READING
Highly Cited
This paper has 25 citations. REVIEW CITATIONS
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 14 citations