Therapeutic potential of β-arrestin- and G protein-biased agonists.

  title={Therapeutic potential of β-arrestin- and G protein-biased agonists.},
  author={Erin J. Whalen and Sudarshan Rajagopal and Robert J. Lefkowitz},
  journal={Trends in molecular medicine},
  volume={17 3},
Members of the seven-transmembrane receptor (7TMR), or G protein-coupled receptor (GPCR), superfamily represent some of the most successful targets of modern drug therapy, with proven efficacy in the treatment of a broad range of human conditions and disease processes. It is now appreciated that β-arrestins, once viewed simply as negative regulators of… CONTINUE READING