Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.

@article{Martin2008TherapeuticPF,
  title={Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.},
  author={Bronwen Martin and Erin Golden and Alex Keselman and Matthew Stone and Mark P. Mattson and Josephine M. Egan and Stuart Maudsley},
  journal={Histology and histopathology},
  year={2008},
  volume={23 2},
  pages={237-50}
}
Huntington's disease (HD) is a tremendously debilitating disorder that strikes relatively young individuals and progresses rapidly over the next ten to fifteen years inducing a loss of cognitive and motor skills and eventually death occurs. The primary locus of the disorder is a polyglutamine expansion of the protein product of the huntingtin (htt) gene. The htt protein appears to be a scaffolding protein that orchestrates the complex assembly of multiple intracellular proteins involved in… CONTINUE READING

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