Therapeutic neutralization of CXCL10 decreases secondary degeneration and functional deficit after spinal cord injury in mice.

@article{Gonzalez2007TherapeuticNO,
  title={Therapeutic neutralization of CXCL10 decreases secondary degeneration and functional deficit after spinal cord injury in mice.},
  author={Rafael Valdes Gonzalez and Michelle J. Hickey and J. M. Martin Espinosa and Gabriel I. Nistor and Thomas E Lane and Hans Keirstead},
  journal={Regenerative medicine},
  year={2007},
  volume={2 5},
  pages={771-83}
}
Inflammation plays a critical role in the secondary degenerative response to spinal cord injury (SCI). The influx of inflammatory cells following SCI is preceded by the expression of specific chemoattractants, including chemokines. The chemokine CXCL10 is a potent T lymphocyte recruiter and has been strongly implicated in the pathology of many CNS disorders. We have previously demonstrated that CXCL10 exacerbates secondary degeneration by blocking the function of CXCL10 prior to SCI. Here we… CONTINUE READING

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