Therapeutic metabolic inhibition: hydrogen sulfide significantly mitigates skeletal muscle ischemia reperfusion injury in vitro and in vivo.

@article{Henderson2010TherapeuticMI,
  title={Therapeutic metabolic inhibition: hydrogen sulfide significantly mitigates skeletal muscle ischemia reperfusion injury in vitro and in vivo.},
  author={Peter W. Henderson and Sunil P. Singh and Andrew L. Weinstein and Vijay V Nagineni and Daniel C Rafii and Daniel J Kadouch and David D Krijgh and Jason A. Spector},
  journal={Plastic and reconstructive surgery},
  year={2010},
  volume={126 6},
  pages={1890-8}
}
BACKGROUND Recent evidence suggests that hydrogen sulfide is capable of mitigating the degree of cellular damage associated with ischemia-reperfusion injury. The purpose of this study was to determine whether it is protective in skeletal muscle. METHODS This study used both in vitro (cultured myotubes subjected to sequential anoxia and normoxia) and in… CONTINUE READING