Therapeutic lung surfactants as carriers for other therapeutics--a matter of vision, courage and determination.


The need for a surface tension reducing agent in the lung was first recognized by von Neergard in 1929. He made this deduction after applying the law of YoungLaplace (which, as early as 1805, described the effects of surface tension forces at curved interfaces) to the proper function of alveoli and bronchioli. Our appreciation and understanding of this… (More)
DOI: 10.1002/ppul.21123