Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats.

  title={Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats.},
  author={Dominic P D'Agostino and Raffaele Pilla and Heather E. Held and Carol S. Landon and Michelle A. Puchowicz and Henri Brunengraber and Csilla Ari and Patrick Arnold and Jay B. Dean},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={304 10},
  • D. D'AgostinoR. Pilla J. Dean
  • Published 15 May 2013
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Central nervous system oxygen toxicity (CNS-OT) seizures occur with little or no warning, and no effective mitigation strategy has been identified. Ketogenic diets (KD) elevate blood ketones and have successfully treated drug-resistant epilepsy. We hypothesized that a ketone ester given orally as R,S-1,3-butanediol acetoacetate diester (BD-AcAc(2)) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Adult male rats (n = 60) were implanted with radiotelemetry units to… 

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