Therapeutic intervention in leukemias that express the activated fms-like tyrosine kinase 3 (FLT3): opportunities and challenges

@article{Sternberg2005TherapeuticII,
  title={Therapeutic intervention in leukemias that express the activated fms-like tyrosine kinase 3 (FLT3): opportunities and challenges},
  author={David W. Sternberg and Jonathan D. Licht},
  journal={Current Opinion in Hematology},
  year={2005},
  volume={12},
  pages={7-13}
}
Purpose of reviewThe fms-like tyrosine kinase 3 (FLT3) receptor tyrosine kinase is now recognized to be a critical mediator in the pathogenesis of myeloid and some lymphoid leukemias. This article reviews recent efforts to disrupt FLT3 signaling in acute myelogenous leukemia and to identify potential therapeutic challenges posed by the acquisition of resistance mutations in these malignancies. Recent findingsSeveral broad classes of FLT3 protein tyrosine kinase inhibitors are undergoing… 
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