Therapeutic interference with leukocyte recirculation in multiple sclerosis.

@article{Sellebjerg2015TherapeuticIW,
  title={Therapeutic interference with leukocyte recirculation in multiple sclerosis.},
  author={Finn Sellebjerg and Per Soelberg S{\o}rensen},
  journal={European journal of neurology},
  year={2015},
  volume={22 3},
  pages={
          434-42
        }
}
Multiple sclerosis (MS) is an immune-mediated disease where T cells are thought to initiate an inflammatory reaction in the brain and spinal cord, resulting in demyelination and axonal pathology. Interfering with the activation and recruitment of immune cells reduces disease activity in MS. We review the mechanism of action and treatment effects of natalizumab and fingolimod, which interfere with the recruitment of pathogenic immune cells in MS. Fingolimod blocks the egress of activated… CONTINUE READING
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