Therapeutic implications of the emerging molecular biology of uveal melanoma.

  title={Therapeutic implications of the emerging molecular biology of uveal melanoma.},
  author={Mrinali Patel and Elizabeth Smyth and Paul B Chapman and Jedd D Wolchok and Gary K. Schwartz and David H Abramson and Richard D. Carvajal},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={17 8},
Uveal melanoma represents the most common primary intraocular malignancy in adults. Although uveal and cutaneous melanomas both arise from melanocytes, uveal melanoma is clinically and biologically distinct from its more common cutaneous counterpart. Metastasis occurs frequently in this disease, and once distant spread occurs, outcomes are poor. No effective systemic therapies are currently available; however, recent advances in our understanding of the biology of this rare and devastating… CONTINUE READING
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