Therapeutic implications of intrinsic or induced angiogenic growth factor redundancy in tumors revealed.

@article{Kerbel2005TherapeuticIO,
  title={Therapeutic implications of intrinsic or induced angiogenic growth factor redundancy in tumors revealed.},
  author={Robert S. Kerbel},
  journal={Cancer cell},
  year={2005},
  volume={8 4},
  pages={269-71}
}
There is a large family of known pro-angiogenic growth factors, many of which can be expressed by a single tumor, especially in advanced stages of disease. Such redundancy, which can be amplified by hypoxia, has long been suspected as a potential cause of acquired resistance when tumors are treated with highly specific targeted antiangiogenic drugs. Definitive preclinical evidence for antiangiogenic drug evasion by alternate pathways of angiogenesis in tumor cells, likely induced by… CONTINUE READING

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