Therapeutic implications of a stem cell model for human breast cancer: a hypothesis.

@article{Selby1983TherapeuticIO,
  title={Therapeutic implications of a stem cell model for human breast cancer: a hypothesis.},
  author={Peter Selby and Jean Pierre Bizzari and Ronald N. Buick},
  journal={Cancer treatment reports},
  year={1983},
  volume={67 7-8},
  pages={659-63}
}
A model for human breast cancer is proposed in which a subpopulation of relatively undifferentiated tumor stem cells gives rise to clones of cells by a process of exponential division. The progeny progressively become more differentiated but lose their proliferative potential. The model implies that breast cancers are heterogeneous with respect to differentiation features such as hormone receptors, both between different clones and within individual clones. Therefore, endocrine therapies are… CONTINUE READING