Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member.

@article{OToole2006TherapeuticIO,
  title={Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member.},
  author={Jennifer M O'Toole and Karen E. Rabenau and Kerri Burns and Dan Lu and Venkat R M Mangalampalli and Paul Balderes and Nicole D Covino and Rajiv Bassi and Marie C Prewett and Kimberly J. Gottfredsen and Megan N. Thobe and Yuan Guo Cheng and Yiwen Li and Daniel J. Hicklin and Zhenping Zhu and Susan E Waltz and Michael J Hayman and Dale L. Ludwig and Daniel de Souza Pereira},
  journal={Cancer research},
  year={2006},
  volume={66 18},
  pages={9162-70}
}
RON is a member of the c-MET receptor tyrosine kinase family. Like c-MET, RON is expressed by a variety of epithelial-derived tumors and cancer cell lines and it is thought to play a functional role in tumorigenesis. To date, antagonists of RON activity have not been tested in vivo to validate RON as a potential cancer target. In this report, we used an antibody phage display library to generate IMC-41A10, a human immunoglobulin G1 (IgG1) antibody that binds with high affinity (ED50 = 0.15 nmol… CONTINUE READING

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Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2005
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