Therapeutic immunization with human immunodeficiency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-infected individuals.

@article{Connolly2008TherapeuticIW,
  title={Therapeutic immunization with human immunodeficiency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-infected individuals.},
  author={Nancy C Connolly and Theresa L Whiteside and Cara C Wilson and Venkatswarlu Kondragunta and Charles R. Rinaldo and Sharon A. Riddler},
  journal={Clinical and vaccine immunology : CVI},
  year={2008},
  volume={15 2},
  pages={
          284-92
        }
}
Treatments for human immunodeficiency virus type 1 (HIV-1)-positive individuals that augment HIV-1 suppression and have potential for achieving long-term control of HIV-1 viremia in the absence of antiretroviral therapy (ART) are urgently needed. We therefore conducted a phase I, clinical safety trial of a dendritic cell (DC)-based vaccination strategy as immunotherapy for HIV-1-positive individuals on ART. We studied 18 HIV-1-positive subjects on ART who underwent leukapheresis to obtain… CONTINUE READING
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