Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children.

@article{Bayir2009TherapeuticHP,
  title={Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children.},
  author={H{\"u}lya A Bayir and P. David Adelson and Stephen R. Wisniewski and P. Shore and Yichen Lai and Danielle S Brown and Keri L Janesko-Feldman and Valerian E Kagan and Patrick M Kochanek},
  journal={Critical care medicine},
  year={2009},
  volume={37 2},
  pages={689-95}
}
OBJECTIVE Oxidative stress contributes to secondary damage after traumatic brain injury (TBI). Hypothermia decreases endogenous antioxidant consumption and lipid peroxidation after experimental cerebral injury. Our objective was to determine the effect of therapeutic hypothermia on oxidative damage after severe TBI in infants and children randomized to moderate hypothermia vs. normothermia. DESIGN Prospective randomized controlled study. SETTING Pediatric intensive care unit of Pittsburgh… CONTINUE READING
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