Therapeutic hypothermia influences cell genesis and survival in the rat hippocampus following global ischemia.

@article{Silasi2011TherapeuticHI,
  title={Therapeutic hypothermia influences cell genesis and survival in the rat hippocampus following global ischemia.},
  author={Gergely Silasi and Frederick Colbourne},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2011},
  volume={31 8},
  pages={1725-35}
}
Delayed hypothermia salvages CA1 neurons from global ischemic injury. However, the effects of this potent neuroprotectant on endogenous repair mechanisms, such as neurogenesis, have not been clearly examined. In this study, we quantified and phenotyped newly generated cells within the hippocampus following untreated and hypothermia-treated ischemia. We first show that CA1 pyramidal neurons did not spontaneously regenerate after ischemia. We then compared the level of neuroprotection when… CONTINUE READING