Therapeutic hypothermia after cardiac arrest

  title={Therapeutic hypothermia after cardiac arrest},
  author={Michael Holzer and Wilhelm Behringer},
  journal={Current Opinion in Anaesthesiology},
Purpose of review Most patients who suffer a cardiac arrest die after the event. Full neurological recovery occurs in only 6–23%. Until recently no specific post-arrest therapy was available to improve outcome. Application of therapeutic hypothermia (32–34°C for 12–24 h) applied after cardiac arrest could help to improve this dreadful situation. This review covers the background of and recent clinical studies into hypothermia after cardiac arrest, and gives some insights into the future of… Expand
Evaluation of remote ischaemic post-conditioning in a pig model of cardiac arrest: A pilot study.
It is proposed that RIPoC applied immediately after ROSC reduces serum concentrations of markers for cell damage and improves end-systolic pressure volume relationship 4h after ROSc. Expand
The effects of mild induced hypothermia on the myocardium: a systematic review
Animal data indicate that mild induced hypothermia results in improved myocardial salvage, reduced infarct size, reduced left ventricular remodelling and better long‐termleft ventricular function, although this has not reached significance in any human study to date. Expand
[Venous thrombosis secondary to catheter insertion for hypothermia after cardiac arrest. Report of one case].
The literature is reviewed to point out the need for a high index of diagnostic suspicion of deep venous thrombosis in these specific setting of out-of-hospital ventricular fibrillation and cardiac arrest. Expand
Damage control resuscitation: a sensible approach to the exsanguinating surgical patient.
This strategy, called "damage control resuscitation", includes the use of permissive hypotension; the prevention and aggressive treatment of hypothermia with both passive and active warming measures; the temporization of acidosis with use of exogenous buffer agents. Expand
Advances in trauma care
The burden of trauma is increasing worldwide [1], but in a very uneven fashion [2, 3]. It is decreasing in the developed world, to the point that trauma surgery as a career is sought by very fewExpand


Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest
In patients who have been successfully resuscitated after cardiac arrest due to ventricular fibrillation, therapeutic mild hypothermia increased the rate of a favorable neurologic outcome and reduced mortality. Expand
Intra-Arrest Cooling Improves Outcomes in a Murine Cardiac Arrest Model
Timing of hypothermia is a crucial determinant of survival in the murine arrest model, and early intra-arrest cooling appears to be significantly better than delayed post-ROSC cooling or normothermic resuscitation. Expand
Hypothermia After Cardiac Arrest: Feasibility and Safety of an External Cooling Protocol
Mild-to-moderate induced hypothermia by use of external cooling blankets after cardiac arrest is feasible and safe, however, external cooling is slow and imprecise. Expand
Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation.
Induction of moderate hypothermia before cardiac arrest has been used successfully since the 1950s to protect the brain against the global ischemia that occurs during some open-heart surgeries. Expand
Mild hypothermia during prolonged cardiopulmonary cerebral resuscitation increases conscious survival in dogs*
Mild or moderate hypothermia during prolonged CPCR in dogs preserves viability of extracerebral organs and improves outcome. Expand
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
This randomized, controlled trial compared the effects of moderate hypothermia and normothermia in patients who remained unconscious after resuscitation from out-of-hospital cardiac arrest to survive to hospital discharge and be discharged to home or to a rehabilitation facility. Expand
Cardiopulmonary cerebral resuscitation using emergency cardiopulmonary bypass, coronary reperfusion therapy and mild hypothermia in patients with cardiac arrest outside the hospital.
The alternative CPCR demonstrated an improvement in the incidence of good recovery and randomized studies of this hypothermia are needed. Expand
Cerebral resuscitation after cardiac arrest: research initiatives and future directions.
  • P. Safar
  • Medicine
  • Annals of emergency medicine
  • 1993
The numbers of conscious survivors have been increased with more effective reperfusion by open-chest CPR or emergency cardiopulmonary bypass, an early hypertensive bout, early post-arrest calcium entry blocker therapy, or mild cerebral hypothermia immediately following cardiac arrest. Expand
Clinical trial of induced hypothermia in comatose survivors of out-of-hospital cardiac arrest.
Compared with historical normothermic controls, outcome was significantly improved and there was no increase in complications when moderate hypothermia was induced in comatose survivors of out-of-hospital cardiac arrest and maintained for 12 hours. Expand
Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: A prospective, randomized study
Mild, resuscitative cerebral hypothermia induced immediately with reperfusions after cardiac arrest improves cerebral functional and morphologic outcome, whereas a delay of 15 mins in initiation of cooling after reperfusion may not improve functional outcome, although it may slightly decrease tissue damage. Expand