Therapeutic hypothermia: neuroprotective mechanisms.

  title={Therapeutic hypothermia: neuroprotective mechanisms.},
  author={Liping Liu and Midori A Yenari},
  journal={Frontiers in bioscience : a journal and virtual library},
Hypothermia has long been known to be a potent putative neuroprotectant. Experimental evidence and clinical experience show that hypothermia protects the brain from cerebral injury. Recent insights into the mechanisms of cerebral ischemia and reperfusion suggest reasons why hypothermia may be an ideal modality for stroke therapy. Hypothermia protects brain tissue in multiple ways. It retards energy depletion, reduces intracellular acidosis, lessens the ischemia related accumulation of… CONTINUE READING
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Mild hypothermia protects experimental ischemia through Fas-FasL pathway

  • L. Liu, M. A. Koike, +4 authors M. A. Yenari
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