Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression.

@article{MarettiMira2011TherapeuticFI,
  title={Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression.},
  author={Ana Cl{\'a}udia Maretti-Mira and Manoel Paes de Oliveira-Neto and Alda Maria Da-Cruz and Milton Adriano Pelli de Oliveira and Nathan Craft and Claude Pirmez},
  journal={Clinical and experimental immunology},
  year={2011},
  volume={163 2},
  pages={
          207-14
        }
}
Cutaneous lesions caused by Leishmania braziliensis infection occasionally heal spontaneously, but with antimonials therapy heal rapidly in approximately 3 weeks. However, about 15% of the cases require several courses of therapy. Matrix metalloproteinase-2 (MMP-2) and MMP-9 are gelatinases that have been implicated in other chronic cutaneous diseases and skin re-epithelialization. These enzymes are controlled by their natural inhibitors [tissue inhibitors of metalloproteinase (TIMPs)] and by… CONTINUE READING
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