Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Alendronate Once-Weekly Study Group.

@article{Schnitzer2000TherapeuticEO,
  title={Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Alendronate Once-Weekly Study Group.},
  author={Thomas J. Schnitzer and H G Bone and Gaetano Crepaldi and Silvano Adami and Michael R Mcclung and Douglas P Kiel and Dieter Felsenberg and R. R. Recker and Richard P Tonino and Christian Roux and Aldo Pinchera and A. Joseph Foldes and Susan L. Greenspan and Michael A Levine and Ronald D Emkey and Arthur C. Santora and Amarjot Kaur and Desmond E. Thompson and John E. Yates and John J. Orloff},
  journal={Aging},
  year={2000},
  volume={12 1},
  pages={1-12}
}
Dosing convenience is a key element in the effective management of any chronic disease, and is particularly important in the long-term management of osteoporosis. Less frequent dosing with any medication may enhance compliance, thereby maximizing the effectiveness of therapy. Animal data support the rationale that once-weekly dosing with alendronate 70 mg (7 times the daily oral treatment dose) could provide similar efficacy to daily dosing with alendronate 10 mg due to its long duration of… CONTINUE READING