Therapeutic entrainment of circadian rhythm disorder by melatonin in a non-blind patient

Abstract

Sirs: Circadian rhythms have evolved as an adaptation to the solar cycle of light and dark. These rhythms have two principal characteristics, the generation by endogenous pacemakers and the entrainment by the lightdark cycle. In his classic experiments with volunteers held under temporal isolation, Aschoff found that the endogenous circadian rhythm has an… (More)
DOI: 10.1007/s004150050228

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