Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication

@article{Bueters2002TherapeuticEO,
  title={Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication},
  author={T. Bueters and B. Groen and M. Danhof and A. IJzerman and H. V. van Helden},
  journal={Archives of Toxicology},
  year={2002},
  volume={76},
  pages={650-656}
}
Abstract. The objective of the present study was to investigate whether reduction of central acetylcholine (ACh) accumulation by adenosine receptor agonists could serve as a generic treatment against organophosphate (OP) poisoning. The OPs studied were tabun (O-ethyl-N-dimethylphosphoramidocyanidate), sarin (isopropylmethylphosphonofluoridate), VX (O-ethyl-S-2-diisopropylaminoethylmethylphosphonothiolate) and parathion (O,O-diethyl-O-(4-nitrophenyl)phosphorothioate). The efficacy of the… Expand
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TLDR
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