Therapeutic efficacy of polyclonal tregs does not require rapamycin in a low-dose irradiation bone marrow transplantation model.

@article{Pilat2011TherapeuticEO,
  title={Therapeutic efficacy of polyclonal tregs does not require rapamycin in a low-dose irradiation bone marrow transplantation model.},
  author={Nina Pilat and Christoph Klaus and Martina Gattringer and Elmar Jaeckel and Fritz Wrba and Dela Golshayan and Ulrike Baranyi and Thomas Wekerle},
  journal={Transplantation},
  year={2011},
  volume={92 3},
  pages={280-8}
}
BACKGROUND Mixed chimerism is an effective strategy for the induction of transplantation tolerance but the toxicity of recipient conditioning makes current bone marrow (BM) transplantation (BMT) protocols unsuitable for widespread clinical application. Therapies promoting BM engraftment under minimal conditioning would facilitate translation of this concept to the clinic. Recently, we have shown that regulatory T cell (Treg) therapy has potent engraftment-enhancing effects in an irradiation… CONTINUE READING