Therapeutic efficacy of multiagent chemotherapy with drug delivery enhancement by blood-brain barrier modification in glioblastoma.

@article{Neuwelt1986TherapeuticEO,
  title={Therapeutic efficacy of multiagent chemotherapy with drug delivery enhancement by blood-brain barrier modification in glioblastoma.},
  author={Edward A Neuwelt and John L. Howieson and Eugene P. Frenkel and H. David Specht and R. W. Weigel and Christopher Buchan and Sally A. Hill},
  journal={Neurosurgery},
  year={1986},
  volume={19 4},
  pages={
          573-82
        }
}
Reversible osmotic blood-brain barrier (BBB) modification was used in 38 patients with glioblastoma to enhance the delivery of chemotherapeutic agents. The patients ranged in age from 14 to 70 years (mean, 43), and all had prior surgery and radiation; 5 had also received systemic chemotherapy. Karnofsky Performance Status (KPS) scores ranged from 60 to 100% (mean, 79) on admission to the treatment program. Barrier modification was achieved by intracarotid or intravertebral artery infusion of… CONTINUE READING
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