Therapeutic effects of quercetin on early inflammation in hypertriglyceridemia-related acute pancreatitis and its mechanism.

@article{Zheng2016TherapeuticEO,
  title={Therapeutic effects of quercetin on early inflammation in hypertriglyceridemia-related acute pancreatitis and its mechanism.},
  author={Junyuan Zheng and Jianghong Wu and Jing Chen and Jie Liu and Yingying Lu and Chunlan Huang and Guoyong Hu and Xing-peng Wang and Yue Zeng},
  journal={Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]},
  year={2016},
  volume={16 2},
  pages={200-10}
}
OBJECTIVE To investigate the therapeutic effects of quercetin on early-stage inflammation in hypertriglyceridemia (HTG)-related acute pancreatitis (AP) both in vivo and in vitro, and its possible mechanism. METHODS In vivo, rats were fed a high-fat diet to induce HTG, and AP was induced by intraperitoneal injection of cerulein (50 μg/kg × 2). Quercetin (100, 150 and 200 mg/kg) was administered by intraperitoneal injection after AP induction. In vitro, rat exocrine acinar cells were… CONTINUE READING
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