Therapeutic effects of micheliolide on a murine model of rheumatoid arthritis.

  title={Therapeutic effects of micheliolide on a murine model of rheumatoid arthritis.},
  author={Hua Xu and Jian Wang and Chijuan Wang and Guoqiang Chang and Yani Lin and Hongju Janet Zhang and Hairui Zhang and Qinghua Li and Tianxiang Pang},
  journal={Molecular medicine reports},
  volume={11 1},
Rheumatoid arthritis (RA) is a systemic autoimmune disease and collagen-induced arthritis (CIA) is an animal model for RA. Micheliolide (MCL) is a novel compound with strong anti-inflammatory effects. The present study was conducted to evaluate the therapeutic effects of MCL on RA. Mice were randomly divided into four groups and the CIA model mice were treated with methotrexate (MTX), MCL and dimethyl sulfoxide. A score associated with the severity of arthritis was assigned on alternate days… CONTINUE READING


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