Therapeutic effects of intra-arterial delivery of bone marrow stromal cells in traumatic brain injury of rats--in vivo cell tracking study by near-infrared fluorescence imaging.

@article{Osanai2012TherapeuticEO,
  title={Therapeutic effects of intra-arterial delivery of bone marrow stromal cells in traumatic brain injury of rats--in vivo cell tracking study by near-infrared fluorescence imaging.},
  author={Toshiya Osanai and Satoshi Kuroda and Taku Sugiyama and Masahito Kawabori and Masaki Ito and Hideo Shichinohe and Yuji Kuge and Kiyohiro Houkin and N. Tamaki and Yoshinobu K Iwasaki},
  journal={Neurosurgery},
  year={2012},
  volume={70 2},
  pages={435-44; discussion 444}
}
BACKGROUND A noninvasive and effective route of cell delivery should be established to yield maximal therapeutic effects for central nervous system (CNS) disorders. OBJECTIVE To elucidate whether intra-arterial delivery of bone marrow stromal cells (BMSCs) significantly promotes functional recovery in traumatic brain injury (TBI) in rats. METHODS Rat BMSCs were transplanted through the ipsilateral internal carotid artery 7 days after the onset of cortical freezing injury. The BMSCs were… CONTINUE READING
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