Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity.

@article{Yoshida1994TherapeuticEO,
  title={Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity.},
  author={Masahiro Yoshida and Takaaki Akaike and Youichiro Wada and Kiyomi Sato and Katsumi Ikeda and Shiro Ueda and Hidekatsu Maeda},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={202 2},
  pages={923-30}
}
We recently found a new class of nitric oxide (NO) antidote, i.e., 2-phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide derivatives (PTIOs). It has a potent inhibitory action against endothelium-derived relaxing factor. Here, we report the effect of a water-soluble carboxy derivative of PTIO (carboxy-PTIO) on endotoxin shock. Endotoxin [lipopolysaccharide (LPS)] (10 mg/kg) was injected into Wistar rats, and the mean arterial blood pressure (MABP), heart rate and urinary parameters were… CONTINUE READING
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