Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia.

@article{Huang2007TherapeuticEO,
  title={Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia.},
  author={Zhen-xing Huang and Zhi-min Kang and Guo-Jun Gu and Guang-neng Peng and Liu Yun and Heng-yi Tao and Wei-Gang Xu and Xuejun Sun and John H Zhang},
  journal={Brain research},
  year={2007},
  volume={1153},
  pages={204-13}
}
It has been established that hyperbaric oxygen (HBO) treatment reduces brain edema, decreases infarct volume, contributes to neurological functional recovery and suppresses apoptosis in suture-induced focal cerebral ischemic animal models. In the present study, we evaluated the therapeutic effect of HBO in an endothelin-1-induced focal cerebral ischemia in rats and explored the associated mechanisms of HBO-induced brain protection. One hundred twenty male Sprague-Dawley rats (280 to 320 g) were… CONTINUE READING