Therapeutic effects of ghrelin on endotoxic shock in rats.

  title={Therapeutic effects of ghrelin on endotoxic shock in rats.},
  author={Lin Chang and Jing Zhao and Jun Yang and Zhaokang Zhang and Junbao Du and Chaoshu Tang},
  journal={European journal of pharmacology},
  volume={473 2-3},
We investigated the effects of ghrelin in a rat endotoxic shock model, and also observed the direct role of endotoxin on ghrelin generation in gastric mucosa. About 55% (11/20) of rats treated with lipopolysaccharide (5 mg/kg i.v.) alone died within 24 h of endotoxin injection. However, administration of ghrelin either at the same time as lipopolysaccharide injection (early treatment) or 12 h after lipopolysaccharide injection (late treatment) significantly decreased the mortality rate and… CONTINUE READING

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