Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.

  title={Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.},
  author={Douglas L. Coleman and Edward H. Leiter and R. W. Schwizer},
  volume={31 9},
Dehydroepiandrosterone (DHEA), a major adrenal secretory steroid in humans, was therapeutic when fed in a concentration of 0.4% to C57BL/KsJ mice with either non-insulin-dependent or insulin-dependent diabetes. Genetically diabetic (db/db) mice of both sexes develop obesity and a glucose intolerance and hyperglycemia associated with insulin resistance by 2 mo of age, and exhibit beta-cell necrosis and islet atrophy by 4 mo. In contrast, DHEA feeding initiated between 1 and 4 mo of age, while… CONTINUE READING


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