Therapeutic effects of cefpirome, a new cephalosporin, on various models of infections in mice and rats.

@article{Arai1990TherapeuticEO,
  title={Therapeutic effects of cefpirome, a new cephalosporin, on various models of infections in mice and rats.},
  author={S. Arai and S. Kobayashi and S. Hayashi},
  journal={The Japanese journal of antibiotics},
  year={1990},
  volume={43 1},
  pages={
          1-8
        }
}
Cefpirome (HR 810) is a new cephalosporin with a 2,3-cyclopentenopyridine group in the 3-position side chain. It was compared with other cephem antibiotics in protective and therapeutic effects on various experimental infections, systemic and local, in mice and rats. HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice… Expand

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The in vitro activity of cefpirome (HR 810), a new cephalosporin antibiotic having a 2,3-cyclopentenopyridine group in the 3-position side chain, showed a broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria and was as active as cefoperazone, an antipseudomonal agent. Expand
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TLDR
HR 810 is a new cephalosporin derivative with an extremely broad antimicrobial spectrum and is active against all bacterial species of clinical relevance, including strains which are frequently resistant towards cep Halosporins of the third generation. Expand
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TLDR
While large amounts of the antibiotic were recovered in the animals' urine, the recovery rate in bile was very low and open the way for the evaluation of HR 810 in humans. Expand