Therapeutic effects of angiotensin (AT1) receptor antagonists: potential contribution of mechanisms other than AT1 receptor blockade.

@article{Schmidt2004TherapeuticEO,
  title={Therapeutic effects of angiotensin (AT1) receptor antagonists: potential contribution of mechanisms other than AT1 receptor blockade.},
  author={Boris Schmidt and Helmut Drexler and Bernhard Schieffer},
  journal={American journal of cardiovascular drugs : drugs, devices, and other interventions},
  year={2004},
  volume={4 6},
  pages={361-8}
}
Blockade of the renin-angiotensin system improves morbidity and mortality of patients with cardiovascular diseases, e.g. arterial hypertension, renal failure, following myocardial infarction and in congestive heart failure. The angiotensin II type 1 (AT(1)) receptor antagonists (angiotensin receptor blockers; ARBs), i.e. losartan, eprosartan, irbesartan and valsartan were developed by computer-based molecule design. Early observations already indicate that the ARBs elicit pleiotropic effects… CONTINUE READING