Therapeutic effects of Nigella sativa on chronic HAART-induced hyperinsulinemia in rats.

@article{Chandra2009TherapeuticEO,
  title={Therapeutic effects of Nigella sativa on chronic HAART-induced hyperinsulinemia in rats.},
  author={Surabhi Chandra and Subramanyam N. Murthy and Debasis Mondal and Krishna C. Agrawal},
  journal={Canadian journal of physiology and pharmacology},
  year={2009},
  volume={87 4},
  pages={
          300-9
        }
}
Prolonged use of highly active antiretroviral therapy (HAART) is associated with insulin resistance in HIV-1-positive patients. Small animal models that recapitulate the long-term effects of HAART may facilitate the identification of therapeutic agents to suppress these side effects. We investigated the protective effects of black seed oil (BSO) from Nigella sativa in Sprague-Dawley rats treated with a daily HAART regimen for 7 months. The antiretroviral drugs, consisting of nelfinavir (200 mg… CONTINUE READING