Therapeutic effects of Clostridium botulinum C3 exoenzyme

Abstract

C3 exoenzyme from Clostridium botulinum, specifically ADP-ribosylates small GTP-binding proteins RhoA, B, and C. ADP-ribosylation causes functional inactivation of Rho proteins resulting in cessation of the complete downstream signaling. Rho proteins are general regulators of a lot of essential cellular functions, among others, the neuronal growth cone. Rho… (More)
DOI: 10.1007/s00210-010-0589-3

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