Therapeutic effects of 1,25-dihydroxyvitamin D and losartan co-administration on myocardial ischemia-reperfusion injury in rats

@inproceedings{Klishadi2014TherapeuticEO,
  title={Therapeutic effects of 1,25-dihydroxyvitamin D and losartan co-administration on myocardial ischemia-reperfusion injury in rats},
  author={Mohsen Sharifi Klishadi and Farideh Zarei and Shahnaz Shekarforoush and Fereshteh Safari and Fatemeh Safari},
  year={2014}
}
Introduction: Studies support the idea that low levels of vitamin D are associated with a higher risk of heart disease. Losartan has also been prescribed as a drug commonly used for treating hypertension. The aim of the current study was to investigate the effects of 1,25-dihydroxyvitamin D in combination with a non-hypotensive dose of losartan on myocardial infarct size, reperfusion-induced arrhythmia and cardiac expression of survival factors in the ischemicreperfused rat heart. Methods: Male… CONTINUE READING

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