Therapeutic effects of β1, 4 mannobiose in a Balb/c mouse model of intranasally-induced pollen allergy.

@article{Yang2013TherapeuticEO,
  title={Therapeutic effects of β1, 4 mannobiose in a Balb/c mouse model of intranasally-induced pollen allergy.},
  author={Chengbo Yang and Prithy Rupa and Hiroyuki Kanatani and Akihiro Nakamura and Masahisa Ibuki and Yoshinori Mine},
  journal={Allergology international : official journal of the Japanese Society of Allergology},
  year={2013},
  volume={62 1},
  pages={65-76}
}
BACKGROUND Nutritional prebiotic supplementation represents an attractive approach for interventions of allergy. In this study, the potential therapeutic effect of β-1, 4 mannobiose (MNB) in a murine model of cedar pollinosis was investigated. METHODS Groups of Balb/c mice were intranasally sensitized to Japanese cedar pollen extract, and subsequently administered with low or high dose MNB. Both intraperitoneal and intranasal challenges were performed to monitor for clinical signs. Frequency… CONTINUE READING

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