Therapeutic effect of urocortin on collagen-induced arthritis by down-regulation of inflammatory and Th1 responses and induction of regulatory T cells.

Abstract

OBJECTIVE To investigate the potential therapeutic action of the immunomodulatory neuropeptide urocortin (UCN) in an experimental model of rheumatoid arthritis (RA). METHODS After disease onset, DBA/1J mice with collagen-induced arthritis (CIA) were treated with UCN, and the incidence, severity (clinical score), and joint histopathology were evaluated… (More)

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@article{GonzlezRey2007TherapeuticEO, title={Therapeutic effect of urocortin on collagen-induced arthritis by down-regulation of inflammatory and Th1 responses and induction of regulatory T cells.}, author={Elena Gonz{\'a}lez-Rey and Alejo Chorny and Nieves Varela and Francisco O'valle and Mario Delgado}, journal={Arthritis and rheumatism}, year={2007}, volume={56 2}, pages={531-43} }