Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses.

@article{Stoop2010TherapeuticEO,
  title={Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses.},
  author={Jeroen Stoop and Rachel Ann Harry and Alexei von Delwig and John Dudley Isaacs and John H. Robinson and Catharien M. U. Hilkens},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 12},
  pages={
          3656-65
        }
}
OBJECTIVE Tolerogenic dendritic cells (DCs) are antigen-presenting cells with an immunosuppressive function. They are a promising immunotherapeutic tool for the attenuation of pathogenic T cell responses in autoimmune arthritis. The aims of this study were to determine the therapeutic action of tolerogenic DCs in a type II collagen-induced arthritis model and to investigate their effects on Th17 cells and other T cell subsets in mice with established arthritis. METHODS Tolerogenic DCs were… CONTINUE READING
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