Therapeutic effect of local administration of low‐dose simvastatin‐conjugated gelatin hydrogel for fracture healing

@article{Fukui2012TherapeuticEO,
  title={Therapeutic effect of local administration of low‐dose simvastatin‐conjugated gelatin hydrogel for fracture healing},
  author={Tomoaki Fukui and Masaaki Ii and Taro Shoji and Tomoyuki Matsumoto and Yutaka Mifune and Yohei Kawakami and Hiroshi Akimaru and Atsuhiko Kawamoto and Tomoya Kuroda and Takashi Saito and Yasuhiko Tabata and Ryosuke Kuroda and Masahiro Kurosaka and Takayuki Asahara},
  journal={Journal of Bone and Mineral Research},
  year={2012},
  volume={27}
}
Several reports have shown the therapeutic effect of statins on bone formation and neovascularization. However, the effect of the systemic administration of statins is limited due to its metabolism in the liver and clearance in the digestive system. In addition, high‐dose administration may cause adverse side effects. To avoid low‐efficacy/frequent side effects of high‐dose statin treatment, we utilized biodegradable gelatin hydrogel as a drug delivery system of statin for fracture healing. A… 
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Simvastatin prodrug micelles target fracture and improve healing.
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Simvastatin-Incorporated Drug Delivery Systems for Bone Regeneration.
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References

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TLDR
A dramatic positive effect is found on biomechanical parameters of fracture healing by simvastatin treatment directly applied to the fracture area, with a 170% larger force at failure as well as a twofold larger energy uptake.
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