Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-β gene and poly I: poly C in a murine lung metastasis model

@article{Sakurai2003TherapeuticEO,
  title={Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-β gene and poly I: poly C in a murine lung metastasis model},
  author={Fuminori Sakurai and Takeshi Terada and Masato Maruyama and Yoshihiko Watanabe and Fumiyoshi Yamashita and Yoshinobu Takakura and Mitsuru Hashida},
  journal={Cancer Gene Therapy},
  year={2003},
  volume={10},
  pages={661-668}
}
We have evaluated and compared the efficacy of systemic administration of lipoplex formulations containing plasmids encoding IFN-β or IFN-γ, and a synthetic double-strand RNA poly I:poly C (pI:pC), a type I IFN inducer, in a lung metastasis model in which colon carcinoma CT-26 cells were inoculated intravenously into immunocompatible mice. Injection of lipoplexes containing plasmid DNA, regardless of IFN gene insertion, stimulated a transient increase in the serum concentration of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

In vitro and in vivo comparative study of chimeric liver-specific promoters.

  • Molecular therapy : the journal of the American Society of Gene Therapy
  • 2003
VIEW 1 EXCERPT

CD4+ T helper cell-independent antitumor response mediated by murine IFN-beta gene delivery in immunocompetent mice.

  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2002

CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo.

  • Molecular therapy : the journal of the American Society of Gene Therapy
  • 2002
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…