Therapeutic effect of intra-articular injection of ribbon-type decoy oligonucleotides for hypoxia inducible factor-1 on joint contracture in an immobilized knee animal model.

@article{Sotobayashi2016TherapeuticEO,
  title={Therapeutic effect of intra-articular injection of ribbon-type decoy oligonucleotides for hypoxia inducible factor-1 on joint contracture in an immobilized knee animal model.},
  author={Daisuke Sotobayashi and Hirohisa Kawahata and Natsuki Anada and Toshio Ogihara and Ryuichi Morishita and Motokuni Aoki},
  journal={The journal of gene medicine},
  year={2016},
  volume={18 8},
  pages={180-92}
}
BACKGROUND Limited range of motion (ROM) as a result of joint contracture in treatment associated with joint immobilization or motor paralysis is a critical issue. However, its molecular mechanism has not been fully clarified and a therapeutic approach is not yet established. METHODS In the present study, we investigated its molecular mechanism, focusing on the role of a transcription factor, hypoxia inducible factor-1 (HIF-1), which regulates the expression of connective tissue growth factor… CONTINUE READING