Therapeutic effect of intra-articular injection of high molecular weight hyaluronic acid on osteoarthritis of the knee.

@article{Namiki1982TherapeuticEO,
  title={Therapeutic effect of intra-articular injection of high molecular weight hyaluronic acid on osteoarthritis of the knee.},
  author={Osamu Namiki and Hideo Toyoshima and Nobuhiro Morisaki},
  journal={International journal of clinical pharmacology, therapy, and toxicology},
  year={1982},
  volume={20 11},
  pages={
          501-7
        }
}
Intra-articular injections of high molecular hyaluronic acid (1% solution) were given at 1- or 2-week intervals to 43 patients with osteoarthritis of the knee. Of the 45 treated knees, 32 (71%) responded favorably. This therapy was effective if the osteoarthritis was of a grade less than moderate; it was not effective in cases with considerable effusion or in those with gross architectural changes. No serious side effects were encountered. We suggest that the beneficial effects of hyaluronic… CONTINUE READING

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