Therapeutic effect of human clonal bone marrow-derived mesenchymal stem cells in severe acute pancreatitis

@article{Jung2015TherapeuticEO,
  title={Therapeutic effect of human clonal bone marrow-derived mesenchymal stem cells in severe acute pancreatitis},
  author={Kyung Hee Jung and Tacghee Yi and Mi kwon Son and Sun U. Song and Soon-Sun Hong},
  journal={Archives of Pharmacal Research},
  year={2015},
  volume={38},
  pages={742-751}
}
Severe acute pancreatitis (SAP), a common necroinflammatory disease initiated by the premature activation of digestive enzymes within the pancreatic acinar cells, is associated with significant morbidity and mortality. In this study, we investigated whether human bone marrow-derived clonal mesenchymal stem cells (hcMSCs), isolated from human bone marrow aspirate according to our newly established isolation protocol, have potential therapeutic effects in SAP. SAP was induced by three… 
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Highly Influential Citations
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Methods Citations
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Results Citations
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33 Citations

Human Bone Marrow Mesenchymal Stromal Cells Attenuate Tissue Injury and Reduce Inflammation in Experimental Acute Pancreatitis

It is demonstrated that hBM- MSC attenuates AP signs and indicating that hMB-MSCtherapy could be a suitable approach for the treatment of inflammatory disease such as AP.

Canine adipose tissue-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating T cells in rats

Results indicate that cAT-MSCs can be effective as a cell-based therapeutic strategy for treatment of SAP in dogs.

Therapeutic Use of Adipose-Derived Stromal Cells in a Murine Model of Acute Pancreatitis

Intravenous delivery of human ASCs markedly reduces pancreatic inflammation in a murine model of AP ASCs which represent an effective therapy for AP.

Granulocyte colony-stimulating factor enhances the therapeutic efficacy of bone marrow mesenchymal stem cell transplantation in rats with experimental acute pancreatitis

G-CSF therapy with BMMSC transplantation improves histological and functional outcomes in rats with experimental AP and shows better recovery in terms of tissue regeneration and blood biochemical levels than other groups.

N-Acetylcysteine enhances the therapeutic efficacy of bone marrow-derived mesenchymal stem cell transplantation in rats with severe acute pancreatitis.

Placental chorionic plate-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating macrophage polarization via secreting TSG-6

Exogenous CP-MSCs tended to colonize in the injured tissue and reduced pancreatic injury and systemic inflammation in SAP rats through inducing M2 polarization of macrophages by secreting TSG-6.

Bone marrow-derived mesenchymal stem cells alleviates renal injury in severe acute pancreatitis via RhoA/Rho kinase.

Results indicated that BMSCs can alleviate SAP rat kidney injury by inhibiting the RhoA/Rho kinase signaling pathways, increase the ZO-1 expression, reduce capillary permeability, blood capillary leakage and improve renal function.

Effect of bone marrow mesenchymal stem cells on RhoA/ROCK signal pathway in severe acute pancreatitis.

Pancreatic expression of RhoA and ROCK I is up-regulated in SAP, with severe pancreatic tissue damage, and BMSCs can alleviate pancreatic injury possibly through decreasing serum inflammatory factor level and inhibiting RHoA/ROCK signal pathway.

Comparative Histological Study on The Effect of Bone Marrow-Derived Mesenchymal Stem Cells Versus Wheat Germ Oil on Acute Pancreatitis in A Rat Model

BMSCs possess better therapeutic efficacy in treating AP compared with WGO, and showed improvement in the biochemical, histological and immunohistochemical results with better results in BMSCs group.

Bone marrow-derived mesenchymal stem cells repair severe acute pancreatitis by secreting miR-181a-5p to target PTEN/Akt/TGF-β1 signaling.

References

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