Therapeutic effect of gene-therapy in combination with local X-irradiation in a mouse malignant melanoma model.

@article{Jin2005TherapeuticEO,
  title={Therapeutic effect of gene-therapy in combination with local X-irradiation in a mouse malignant melanoma model.},
  author={Guang-Hui Jin and S Jin and Yang Liu and Rui-Ming Xu and Jian-Zheng Yang and Xue-Na Pan and Shu-zheng Liu},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={330 3},
  pages={975-81}
}
Plasmid containing mIL-18 and B7.1 genes downstream of Egr-1 promoter was constructed and used in gene-radiotherapy on malignant melanoma in C57BL/6J mice implanted with B16 cells followed by exploration of the immunologic mechanism of the therapeutic effect. The treatment with plasmid pEgr-IL-18-B7.1 plus local X-irradiation showed more effective suppression of tumor growth than the treatment with radiation alone, pEgr-IL-18-B7.1 alone, or single gene pEgr-IL-18 (or pEgr-B7.1) combined with… CONTINUE READING

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