Therapeutic effect of anti-C-X-C motif chemokine 10 (CXCL10) antibody on C protein-induced myositis mouse

@inproceedings{Kim2014TherapeuticEO,
  title={Therapeutic effect of anti-C-X-C motif chemokine 10 (CXCL10) antibody on C protein-induced myositis mouse},
  author={Jinhyun Kim and Ji Yong Choi and Sung Hye Park and Seung Hee Yang and Ji Ah Park and Kichul Shin and Eun Young Lee and Hiroshi Kawachi and Hitoshi Kohsaka and Yeong Wook Song},
  booktitle={Arthritis research & therapy},
  year={2014}
}
IntroductionC-X-C motif chemokine 10 (CXCL10) is a chemokine that plays a critical role in the infiltration of T cells in autoimmune diseases and is reported to be expressed in muscle tissue of polymyositis. To determine the therapeutic efficacy of CXCL10 blockade, we investigated the role of CXCL10 and the effect of anti-CXCL10 antibody treatment in C protein-induced myositis (CIM), an animal model of polymyositis.MethodsCIM was induced with human skeletal muscle C protein fragment in female… CONTINUE READING
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