Therapeutic effect of anthracene-based anticancer agent ethonafide in an animal model of multiple sclerosis.

@article{Piao2007TherapeuticEO,
  title={Therapeutic effect of anthracene-based anticancer agent ethonafide in an animal model of multiple sclerosis.},
  author={Wen-Hua Piao and Rudy Wong and Xue-feng Bai and Jianhua Huang and Denise Campagnolo and Robert T. Dorr and Timothy L. Vollmer and Fu-dong Shi},
  journal={Journal of immunology},
  year={2007},
  volume={179 11},
  pages={7415-23}
}
The side effects of cancer chemotherapeutic agents such as mitoxantrone (MIT) in multiple sclerosis (MS) patients justify the search for less toxic drugs. Ethonafide is an anthracene-based antineoplastic drug similar to MIT. With reference to MIT, we examined the effect of ethonafide on experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice, an… CONTINUE READING