Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC-MS.

@article{Choong2009TherapeuticDM,
  title={Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC-MS.},
  author={Eva Choong and Serge Rudaz and Astrid Kottelat and Davy Guillarme and J. -L. Veuthey and Chin B Eap},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2009},
  volume={50 5},
  pages={
          1000-8
        }
}
A simple and sensitive LC-MS method was developed and validated for the simultaneous quantification of aripiprazole (ARI), atomoxetine (ATO), duloxetine (DUL), clozapine (CLO), olanzapine (OLA), sertindole (STN), venlafaxine (VEN) and their active metabolites dehydroaripiprazole (DARI), norclozapine (NCLO), dehydrosertindole (DSTN) and O-desmethylvenlafaxine (OVEN) in human plasma. The above mentioned compounds and the internal standard (remoxipride) were extracted from 0.5 mL plasma by solid… CONTINUE READING
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