Therapeutic drug monitoring of cyclosporine-lipoprotein levels.

@article{Yau1991TherapeuticDM,
  title={Therapeutic drug monitoring of cyclosporine-lipoprotein levels.},
  author={John Yau and Lane J. Brunner and Gabriel L{\'o}pez-Berestein and Charles F Lemaistre and D. Russell Luke},
  journal={Pharmacotherapy},
  year={1991},
  volume={11 4},
  pages={291-5}
}
Cyclosporine therapy is complicated by nephrotoxicity that is not predicted by drug levels. In this study serial trough blood samples were obtained from 11 allogeneic marrow transplant recipients after initiation of intravenous cyclosporine 2 mg/kg every 12 hours for a period extending 4 weeks after transplantation. Renal dysfunction, assessed by an increase in serum creatinine levels to twice baseline values or when greater than 175 mumol/L, was found in four patients. No associations between… CONTINUE READING

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