Therapeutic drug monitoring of immunosuppressant drugs.

@article{Johnston1999TherapeuticDM,
  title={Therapeutic drug monitoring of immunosuppressant drugs.},
  author={Atholl Johnston and David W Holt},
  journal={British journal of clinical pharmacology},
  year={1999},
  volume={47 4},
  pages={
          339-50
        }
}
  • A. JohnstonD. Holt
  • Published 1 April 1999
  • Medicine, Biology
  • British journal of clinical pharmacology
Individualizing a patient’s drug therapy to obtain the optimum balance between therapeutic efficacy and the occurrence of adverse events is the physician’s goal. However, achieving this goal is not always straight forward, being complicated by within and between patient variability in both pharmacokinetics and pharmacodynamics. In the early 1960s new analytical techniques became available allowing the measurement of the low drug concentrations seen in biological fluids during drug treatment… 

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...

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